As cutaneous squamous cell carcinoma (CSCC) progresses,
so does its complexity—and its threat.1
Take a deeper look

CSCC is a commonly occurring type of cancer.
Annual US incidence of CSCC is estimated to be2-4

Annual US incidence of CSCC is estimated to be ~700,000 and rising.*

and rising.

*As of 2012.

Read about the rising
incidence of CSCC

While early-stage CSCC generally has a good prognosis, certain tumor and patient factors can indicate a greater risk for recurrence or metastasis.5

CSCC: Invasion into subcutaneous fat.

Invasion into
subcutaneous fat

CSCC: Nodal involvement.

Nodal
involvement

CSCC: Perineural invasion.

Perineural
invasion

CSCC: Growth in desmoplastic or infiltrative pattern.

Growth in desmoplastic
or infiltrative pattern

Recognize the signs and symptoms
indicating a higher risk
for disease progression

More than

More than 70% of disease specific death were reported to be caused by locoregional disease that has not distantly metastasized (M0).

of disease-specific death was reported to be caused by locoregional disease
that has not distantly metastasized (M0).3,6,7

Learn more about the poor
prognosis of advanced disease
Learn more on the next page

References: 1. Migden MR, Rischin D, Schmults CD, et al. PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma. N Engl J Med. 2018;379(4):341-351. 2. Rogers HW, Weinstock MA, Feldman SR, Coldiron BM. Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the US population, 2012. JAMA Dermatol. 2015;151(10):1081-1086. 3. Burton KA, Ashack KA, Khachemoune A. Cutaneous squamous cell carcinoma: a review of high-risk and metastatic disease. Am J Clin Dermatol. 2016;17(5):491-508. 4. Karia PS, Han J, Schmults CD. Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. J Am Acad Dermatol. 2013;68(6):957-966. 5. Jennings L, Schmults CD. Management of high-risk cutaneous squamous cell carcinoma. J Clin Aesthet Dermatol. 2010;3(4):39-48. 6. Brunner M, Veness MJ, Ch’ng S, Elliott M, Clark JR. Distant metastases from cutaneous squamous cell carcinoma—analysis of AJCC stage IV. Head Neck. 2013;35(1):72-75. 7. Oddone N, Morgan GJ, Palme CE, et al. Metastatic cutaneous squamous cell carcinoma of the head and neck: the immunosuppression, treatment, extranodal spread, and margin status (ITEM) prognostic score to predict outcome and the need to improve survival. Cancer. 2009;115(9):1883-1891.