As cutaneous squamous cell carcinoma (CSCC) progresses,
so does its complexity—and its threat.1
Take a deeper look

CSCC is a commonly occurring type of cancer.
Annual US incidence of CSCC is estimated to be2-4

Annual US incidence of CSCC is estimated to be ~700,000 and rising.*

and rising.

*As of 2012.

Read about the rising
incidence of CSCC

While early-stage CSCC generally has a good prognosis, certain tumor and patient factors can indicate a greater risk for recurrence or metastasis.5

CSCC: Invasion into subcutaneous fat.

Invasion into
subcutaneous fat

CSCC: Nodal involvement.


CSCC: Perineural invasion.


CSCC: Growth in desmoplastic or infiltrative pattern.

Growth in desmoplastic
or infiltrative pattern

Recognize the signs and symptoms
indicating a higher risk
for disease progression

More than

More than 70% of disease specific death were reported to be caused by locoregional disease that has not distantly metastasized (M0).

of disease-specific death was reported to be caused by locoregional disease
that has not distantly metastasized (M0).3,6,7

Learn more about the poor
prognosis of advanced disease

References: 1. Migden MR, Rischin D, Schmults CD, et al. PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma. N Engl J Med. 2018;379(4):341-351. 2. Rogers HW, Weinstock MA, Feldman SR, Coldiron BM. Incidence estimate of nonmelanoma skin cancer (keratinocyte carcinomas) in the US population, 2012. JAMA Dermatol. 2015;151(10):1081-1086. 3. Burton KA, Ashack KA, Khachemoune A. Cutaneous squamous cell carcinoma: a review of high-risk and metastatic disease. Am J Clin Dermatol. 2016;17(5):491-508. 4. Karia PS, Han J, Schmults CD. Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012. J Am Acad Dermatol. 2013;68(6):957-966. 5. Jennings L, Schmults CD. Management of high-risk cutaneous squamous cell carcinoma. J Clin Aesthet Dermatol. 2010;3(4):39-48. 6. Brunner M, Veness MJ, Ch’ng S, Elliott M, Clark JR. Distant metastases from cutaneous squamous cell carcinoma—analysis of AJCC stage IV. Head Neck. 2013;35(1):72-75. 7. Oddone N, Morgan GJ, Palme CE, et al. Metastatic cutaneous squamous cell carcinoma of the head and neck: the immunosuppression, treatment, extranodal spread, and margin status (ITEM) prognostic score to predict outcome and the need to improve survival. Cancer. 2009;115(9):1883-1891.